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Why women between the ages of 18 and 48, are at higher risk of blood clots. #COVID19 Vaccination

 

Why younger women are more exposed to risk of blood clots, whether or not they're vaccinated

* J&J's COVID-19 vaccine distribution is paused after reports of 6 rare, severe blood clots.

* The clots, seen with another blood condition, aren't an equivalent as those linked to contraception .

* The contraception pill and pregnancy play into younger women's higher risk of blood clots.

The US rollout of Johnson & Johnson's COVID-19 vaccine is on pause as experts evaluate six cases of severe blood clots within the brain possibly linked to the shots.

It's unclear if the vaccines cause these clots or if it's just a coincidence.

On one hand, the sort of grume seen in conjunction with another blood condition within the six J&J cases is so rare within the general population its prevalence is unknown. That raises red flags that the shot could play a task .

Why younger women are more exposed to risk of blood clots, whether or not they're vaccinated


On another hand, all six cases of post-J&J shot clots were in women between the ages of 18 and 48, a gaggle at higher risk of blood clots anyway.

Similarly, most grume cases that occurred after AstraZeneca's COVID-19 vaccine in Europe were in women under 55. the ecu Medicines Agency has said the shots themselves weren't the cause.

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Young women are at a better risk of developing certain sorts of blood clots no matter their vaccine status, Mary Cushman, a professor of drugs at the University of Vermont's Larner College of drugs , told Insider. Hormonal contraception and pregnancy may play a task during this elevated risk.

Birth control pills and pregnancy both increase the danger of blood clots

Young women are at a comparatively high risk for blood clots since they're presumably to require the contraception pill or get pregnant, which both increase the chances of developing a clot, Cushman told Insider.

Estrogen, a steroid hormone that's in most oral contraceptives and spikes during pregnancy, is one reason for that elevated risk, Insider previously reported. The hormone has also been found to affect how immune cells answer flu vaccines.

Specifically, the US Food and Drug Administration estimates that between 3 and 9 out of 10,000 women who take certain contraception pills will develop a grume annually , compared to 1 to five women per 10,000 who don't have risk factors for blood clots.

The risk of getting a grume as a side effect of the pill is above the likelihood of clotting thanks to the vaccine. Scientists have known about this risk factor for many years , however, it's still rare, as a recent TikTok video acknowledged .

"Millions of girls everywhere take the pill , and amongst the many side effects that accompany the pill - one among which is death - there is a 6 in 10,000 chance of getting a grume ," TikToker alysselizabeth said within the video.

Still, the danger of clotting post-vaccine versus the danger associated with contraception isn't an apples-to-apples comparison. There's much more data on birth control-associated clots, but tons of it's flawed and outdated. Plus, the precise sort of brain clots seen after J&J vaccine, also as its presentation with low platelet count, differentiates them from the clots commonest among contraception pill users.

 

"This may be a different clinical entity than blood clots related to oral contraceptives," Dr. Melanie Swift, co-chair of the Mayo Clinic COVID-19 Vaccine Allocation and Distribution Work Group, told Insider.

There are other risk factors for blood clots - including COVID-19

Obesity and genetic factors also can increase someone's risk of developing a grume , Cushman said. Physical activity and other healthy lifestyle choices can help manage that risk.

"It's always really important to remain active, avoid sedentary time, keep to a healthy weight, and have a healthy diet," Cushman said. "And if you're using an pill , or if you've got obesity, maybe just ratchet up your awareness a touch bit, but don't avoid the shot."

She added that COVID-19 has been linked to deadly blood clots, too - so getting vaccinated will help prevent clots by lowering your chance of getting sick from the coronavirus.

"The bottom line is that the danger of adverse health consequences from COVID-19 far outweighs any risk of the shot," Cushman said.

Added Swift: "I would tell everyone to possess confidence within the vaccine safety monitoring system within the US. What a tremendous feat to possess detected a sign of only 6 people among millions. ... We don't want this point out for one brand of vaccine to stall vaccination efforts overall because that might end in more needless lives lost to the pandemic."





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